Papers:

  1. Thomas A. Cornell , Jing Fu , Stephanie H. Newland , and Brendan P. Orner, "Detection of Specific Protein-Protein Interactions in Nanocages by Engineering Bipartite FlAsH Binding Sites", J. Am. Chem. Soc., 2013, 135, 44.




  2. Maziar S. Ardejani and Brendan P. Orner, "Obey the Peptide Assembly Rules ", Science, 2013, 340, 561.
















  3. Maziar S. Ardejani , Xiao Ling Chok , Ce Jin Foo and Brendan P. Orner, "Complete shift of ferritin oligomerization toward nanocage assembly via engineered protein–protein interactions ", Chem. Commun., 2013, 49, 3528



  4. Yu Zhang, Jing Fu, Sze Y. Chee, Emmiline X. W. Ang Brendan P. Orner*, "Rational disruption of the oligomerization of the mini-ferritin E. coli DPS through protein-protein interface mutation", Protein Science, 2011, 20, 1907. The paper appears on the front cover of the journal.




  5. Yu Zhang, Brendan P. Orner*, "Self-Assembly in the Ferritin Nano-Cage Protein Superfamily", Int. J. Mol. Sci., 2011, 12, 5406.




  6. Maziar S. Ardejani, Noel X. Li, and Brendan P. Orner*, "Stabilization of a Protein Nanocage through the Plugging of a Protein–Protein Interfacial Water Pocket", Biochemistry, 2011, 50, 4029.


  7. Fahriye Ceyda Dudak, Ismail Hakki Boyaci, and Brendan P. Orner*, "The Discovery of Small-Molecule Mimicking Peptides through Phage Display", Molecules,  2011, 16, 774. The corresponding author was the guest editor of the special issue on "Phage Display of Combinatorial Libraries". 


  8. Lingyin Li, Brendan P. Orner, Tao Huang, Andrew P. Hinck and Laura L. Kiessling*, "Peptide ligands that use a novel binding site to target both TGF-b receptors", Molecular BioSystems, 2010, 6, 2392. This paper has been selected for the front cover of Molecular BioSystems.


  9. Brendan Patrick Orner *, "The First Asian Chemical Biology Conference Meets at Seoul National University", ACS Chemical Biology, 2010, 5, 725.


  10. Rongli Fan, Shu Wen Chew, Vee Vee Cheong, Brendan Patrick Orner*, "Fabrication of Gold Nanoparticles Inside Unmodified Horse Spleen Apoferritin", Small, 2010, 6, 1483.


  11. Ratmir Derda, Samira Musah, Brendan P. Orner, Joseph R. Klim, Lingyin Li, and Laura L. Kiessling*
    "High-Throughput Discovery of Synthetic Surfaces That Support Proliferation of Pluripotent Cells" J. Am. Chem. Soc., 2010, 132, 1289.


  12. Yu Zhang, Siti Raudah Mohamed Lazim, Huihian Teo, Gwenda W. S. Teo, Rongli Fan, Xiaoming Sun, Brendan P. Orner* “Alanine-shaving Mutagenesis to Determine Key Interfacial Residues Governing the Assembly of a Nano-cage Maxi-ferritin”, Journal of Biological Chemistry, 2010, 285, 12078. (This article has been chosen as "paper of the week" by JBC editorial board and also appeared on the ACS Chemical Biology's Spotlight . )


  13. Rongli Fan, Aimee L. Boyle, Vee Vee Cheong, See Liang Ng, Brendan P. Orner* “A Helix Swapping Study of Two Protein Cages”, Biochemistry, 2009, 48, 5623.


  14. Limin Yu, Peggy Shuang, Elizabeth Yee Yen Mui, Jennifer C. McKelvie, Thi Phuong Tu Phama, Yan Wen Yap, Wan Qing Wong, Jiawen Wu, Weiqiao Deng, Brendan P. Orner* “Phage display screening against a set of targets to establish peptide-based sugar mimetics and molecular docking to predict binding site”, Bioorganic & Medicinal Chemistry, 2009, 17, 4825


  15. Yueqin Fang, Wan Qing Wong, Yan Wen Yap, Brendan P. Orner* “Stem Cells and Combinatorial Science”, Combinatorial Chemistry & High Throughput Screening, 2007, 10, 635.
     

  16. Ratmir Derda, Lingyin Li, Brendan P. Orner, Rachel L. Lewis, James A. Thomson, Laura L. Kiessling, "Defined Substrates for Human Embryonic Stem Cell Growth Identified from Surface Arrays", ACS Chemical Biology, 2007, 2, 347.
     

  17. Yueqin Fang, Brendan P. Orner*, “Induction of Pluripotency in Fibroblasts Through the Expression of Only Four Nuclear Proteins”, ACS Chemical Biology, 2006, 1, 557.
     

  18. Brendan P. Orner, Lin Liu, Regina M. Murphy, Laura L. Kiessling, "Phage Display Affords Peptides that Modulate β-Amyloid Aggregation", J. Am. Chem. Soc., 2006, 128, 11881.
     

  19. Hang Yin, Gui-in Lee, Kristine A. Sedey, Olaf Kutzki, Hyung Soon Park, Brendan P. Orner, Justin T. Ernst, Hong- Gang Wang, Said M. Sebti, Andrew D. Hamilton, "Terphenyl-Based Bak BH3 α-Helical Proteomimetics as Low- Molecular Weight Antagonists of Bcl-xL", J. Am. Chem. Soc., 2005, 127, 10191. (note: This paper is attributed to “Brendan P. Omer” in web of science)
     

  20. Brendan P. Orner, Ratmir Derda, Rachel L. Lewis, James A. Thomson, Laura L. Kiessling, "Arrays for the Combinatorial Exploration of Cell Adhesion", J. Am. Chem. Soc., 2004, 126, 10808.
     

  21. Olaf Kutzki, Hung-Sun Park, Justin T. Ernst, Brendan P. Orner, Hang Yin, Andrew D. Hamilton, "Development of a Potent Bcl-xL Antagonist Based on α-Helix Mimicry", J. Am. Chem. Soc., 2002, 124, 11838.
     

  22. Brendan P. Orner, Xavier Salvatella, Javier de Mandoza, Ernest Giralt, Andrew D. Hamilton, "De Novo Protein Surface Design: Use of Cation-π Interactions to Enhance Binding Between an a-Helical Peptide and a Cationic Molecule in 50% Aqueous Solution", Angew. Chem., Int. Ed. Engl., 2002, 41, 117.
     

  23. Brendan P. Orner, Justin T. Ernst, Andrew D. Hamilton, "Towards Proteomimetics: Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix", J. Am. Chem. Soc., 2001, 123, 5382.
     

  24. Brendan P. Orner, Andrew D. Hamilton, "The Guanidinium Group in Molecular Recognition: Design and Synthetic Approaches", J. Inclusion Penom. Macrocyc. Chem., 2001, 41, 141.
     

  25. Mark W. Peczuh, Brendan P. Orner, Andrew D. Hamilton, "In Recognition of Proteins", Chemistry in Britain, 2000, 36, 43-45.
     

  26. Brian Linton, Andrew J. Carr, Brendan P. Orner, Andrew D. Hamilton, "A Versatile One-Pot Synthesis of 1,2- Substituted Guanidines from Carbamoyl Isothiocyanates", J. Org. Chem., 2000, 65, 1566.
     

Patents:

 

  1. Laura L. Kiessling, Ratmir Derda, Brendan P. Orner, James A. Thomson “Defined Surfaces of Self-Assembled Monolayers and Stem Cells” US Patent No.: 13/291,555 Feb. 04, 2014.

  2. Brendan Orner, Fan Rongli, Chew Shu Wen, Cheong Vee Vee “Method For The Fabrication Of Gold Nanoparticles Inside Protein Cages Requiring No Modification Of The Protein” US Provisional Patent Application 61/386,069 Sept. 24, 2010.

  3. Laura L. Kiessling, James A. Thomson, Brendan P. Orner, Ratmir Derda, "Combinatorial Approach to Screen for Stem Cell Adhesion and Long-Term Proliferation", U. S. Patent Application: 20070207543 Sept. 6, 2007 (Preliminary U. S. Patent P05364US April 20, 2005).

  4. Andrew D. Hamilton, Justin T. Ernst, Brendan P. Orner, "Proteomimetic Compounds and Methods", U. S. Patent, 20050215563 September 29, 2005 (Prelim patent: 20030008882, May 8, 2002).